This suggests that passive immunization with tau antibodies is really a practical therapeutic goal and that the CSF volume of p-tau 262/356 or in the microtubule binding domain (MTBD) can function a helpful biomarker of tau pathology to observe tau therapeutics in medical trials,” he wrote.The trial works by using a sentinel design, whereby the f… Read More
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Signature to Framework. Alanine scan signatures clearly show how substitution with alanine residues throughout tau’s repeat domains impact incorporation into rising fibrils (left).From the therapeutic viewpoint, the implications of this work are transformative. It is currently obvious that homozygosity may not be needed for defense, boosting the … Read More